Lyme Disease, MRSA, Sepsis, and Stubborn Infections
All I maintain is that on this earth there are pestilences and there are victims, and it's up to us, so far as possible, not to join forces with the pestilences. That may sound simple to the point of childishness; I can't judge if it's simple, but I know it's true. You see, I've heard such quantities of arguments, which very nearly turned my head, and turned other people's heads enough to make them approve of murder; and I'd come to realize that all our troubles spring from our failure to use plain, clean-cut language.--The Plague, Albert Camus
Tick-borne Borrelia microbes that cause Lyme disease and other "facultative anaerobes" thrive in bone and connective tissue where tissue oxygenation and perfusion are marginal. Hyperbaric oxygen treatment enhances antibiotic potency and helps to treat these stubborn infections. However, the effectiveness of hyperbaric oxygen is limited to its ability to increase blood plasma oxygen saturation. Hemoglobin in red cells binds avidly to oxygen, and 90% of blood oxygen is bound to hemoglobin, which is normally 100% saturated at normal atmospheric pressures. Thus hyperbaric oxygen treatment increases blood oxygen content only slightly, and it cannot release oxygen from hemoglobin.(1)
1. L. S. Coleman, Four Forgotten Giants of Anesthesia History. Journal of Anesthesia and Surgery 3, 1-17 (2015).