Lyme Disease, MRSA, Sepsis, and Stubborn Infections

All I maintain is that on this earth there are pestilences and there are victims, and it's up to us, so far as possible, not to join forces with the pestilences. That may sound simple to the point of childishness; I can't judge if it's simple, but I know it's true.  You see, I've heard such quantities of arguments, which very nearly turned my head, and turned other people's heads enough to make them approve of murder; and I'd come to realize that all our troubles spring from our failure to use plain, clean-cut language.--The Plague, Albert Camus 


 

 

Microbial invasion triggers blood "complement cascade" enzymes and MSM hyperactivity that closes the capillary gate, inhibits tissue perfusion and oxygenation, and frustrates antibiotic potency and penetration. Treatment with combinations of CO2 supplementation, opioid analgesia, general anesthesia and thrombin inhibition can rapidly relieve the symptoms of MSM hyperactivity, and optimize antibiotic potency and penetration by opening the capillary gate, maximizing tissue perfusion and oxygenation, and releasing bactericidal nitric oxide from capillary walls. 

Tick-borne Borrelia microbes that cause Lyme disease and other "facultative anaerobes"  thrive in bone and connective tissue where tissue oxygenation and perfusion are marginal. Hyperbaric oxygen treatment enhances antibiotic potency and helps to treat these stubborn infections. However, the effectiveness of hyperbaric oxygen is limited to its ability to increase blood plasma oxygen saturation. Hemoglobin in red cells binds avidly to oxygen, and 90% of blood oxygen is bound to hemoglobin, which is normally 100% saturated at normal atmospheric pressures. Thus hyperbaric oxygen treatment increases blood oxygen content only slightly, and it cannot release oxygen from hemoglobin.(1)

Carbogen (a pressurized mixture of 5% carbon and 95% oxygen) inhaled by mask can enhance tissue oxygenation more effectively than hyperbaric oxygen treatment, because carbon dioxide releases oxygen from the hemoglobin molecule. CO2 also opens the capillary gate, increases tissue perfusion and oxygenation, and releases bactericidal nitric oxide from capillary walls. Antibiotic effectiveness can be further enhanced by general endotracheal anesthesia supplemented by hypercarbia, opioids, and EDTA to maximize tissue perfusion, tissue oxygenation, and nitric oxide release.  

1. L. S. Coleman, Four Forgotten Giants of Anesthesia History. Journal of Anesthesia and Surgery 3, 1-17 (2015).