Critical Illnesses and Syndromes

“Beware of false knowledge; it is more dangerous than ignorance.” —George Bernard Shaw

Stress theory provides an explanation of critical illnesses. These are all "syndromes" ----unexplained illnesses with distinguishing symptoms. What they all have in common is excessive leakage of tissue factor into systemic blood circulation or adjacent tissues for one reason or another. Tissue factor activates factor VII, which acts as a powerful "trigger" for the interaction of factors VII, VIII, IX and X. The complement cascade enzymes play a complementary role in many of these conditions. Tissues with high concentrations of tissue factor are "targets" in all these life-threatening conditions. Brain, lung, retina, spinal cord, peripheral nerves, autonomic ganglia, peri-arterial tissues, gonads, cervix, tongue, placenta, and amniotic fluid are all rich in tissue factor. Thus, as an example, brain trauma is associated with high mortality, because it readily releases tissue factor into systemic circulation, triggers systemic factor VII activity, and induces positive feedback that ignites systemic MSM hyperactivity. The lung is typically the first organ affected, because it is rich in tissue factor and intensely innervated with sympathetic nerve endings. This is called "ARDS" (Adult Respiratory Distress Syndrome) but this soon evolves into "MOFS" (Multi-Organ Failure Syndrome) as systemic MSM hyperactivity causes other organs to fail.  

Asthma is caused by inhaling toxic airborne substances, such as automobile exhaust, herbicides, and pesticides that induce thrombin and soluble fibrin generation and inflammation in air passages, which exaggerates the permeability of the vascular endothelium in affected tissues. as factor VII penetrates through the vascular endothelium into the tissues lining airway passages, it interacts with tissue factor to generate  soluble fibrin exudates that reduce the functional diameter of airway passages. Inhalation is little affected, because it expands airway diameters and reduces flow resistance, but “air trapping” occurs during exhalation, when air passages are reduced in diameter. This causes severe emotional distress that exaggerates sympathetic nervous system activity and aggravates MSM hyperactivity. Children are more vulnerable than adults because of the small diameter of their airway passages causes exponential exaggeration of turbulent air flow resistance.

Pneumonia and influenza are caused by microbial invasion of the lung, which provokes violent inflammatory MSM hyperactivity that floods the lung with soluble fibrin exudates and disrupts gas exchange.

Systemic Inflammatory Response Syndrome (SIRS) first appeared in cardiac surgery patients in the early 1990's after insurance reimbursements were changed to promote "fast tracking" (rapid discharge) whereupon cardiac anesthesiologists abandoned opioid supplementation. The resulting inadequate stress control during cardiac bypass caused postoperative MSM hyperactivity that manifested as severe pulmonary inflammation. 

Sepsis is MSM hyperactivity induced by microbes invading systemic circulation, which triggers complement cascade enzymes, causing systemic thrombin generation that induces systemic inflammation that increases the permeability of the vascular endothelium and allows soluble fibrin to escape the vascular system and enter extravascular tissues, causing edema and organ disruption that undermines antibiotic penetration and potency.

Ebola, Legionnaire's Disease, and coccidiomycosis pneumonia are severe MSM hyperactivity due to pulmonary bacterial infestation that causes acute, severe inflammation of lung tissues.  

Adult Respiratory Distress Syndrome (ARDS) is the first manifestation of Multi-Organ Failure Syndrome (MOFS) due to the rich concentration of tissue factor in pulmonary tissues. It is most commonly caused by combinations of severe trauma plus sepsis.  As positive feedback worsens the MSM hyperactivity, additional organs are disrupted by inflammation and soluble fibrin invasion, often with lethal result. Most victims are elderly and suffer from subclinical accelerated capillary senescence, which is an additional source of stress. Severe ARDS is often complicated by pulmonary fibrosis because soluble fibrin exudates promote collagen production in the lung. 

Eclampsia is essentially the same as MOFS except that pregnancy is the primary source of stress, because amniotic fluid is rich in tissue factor that sometimes leaks into systemic circulation and activates factor VII, causing MSM hyperactivity. The placenta is also rich in tissue factor that can leak into systemic circulation. Most cases are precipitated by combinations of accelerated capillary senescence (which explains why smoking is associated with eclampsia), occult urinary tract infection, and the onset of labor, which suddenly exaggerates SNS activity, metabolic demand, and cardiac output. The onset of labor can also cause amniotic fluid embolus wherein large quantities of tissue factor enter systemic circulation and precipitate disseminated intravascular coagulation (DIC)

Severe Burns and brain injuries are associated with high mortality because they release large quantities of tissue factor into blood circulation

Spinal Cord Shock Syndrome occurs when spinal cord trauma exposes tissue factor and activates tissue repair activity in the affected spinal cord tissue, causing inflammation, edema, and swelling. For a few hours the spinal cord functions normally, but as the swelling progressively compromises perfusion in the affected spinal cord tissue, nervous activity deteriorates, and ischemic necrosis and sclerosis can cause functional spinal cord transection. 

Treatment consisting of combinations of anesthesia, analgesia and thrombin inhibition using EDTA, trisodium citrate or magnesium sulphate can mitigate MSM hyperactivity so as to enhance antibiotic effectiveness, inhibit inflammation, restore normal permeability of the vascular endothelium, preserve organ function, restore tissue perfusion and oxygation to infarcted tissues, promote healing, salvage function, and save lives.